Cirs 1519

cirs 1519

What is chronic inflammatory response syndrome (CIRS)?

Chronic Inflammatory Response Syndrome (CIRS) is a multi-system, multi-symptom illness caused by inhaling biotoxins and inflammagens produced by micro-organisms such as mould, bacteria, and actinomycetes found in water-damaged buildings (WDB).

What is CIRs and how is it characterised?

Rather, CIRS is characterised primarily by an over-response of the innate immune system. Inflammation is a natural part of the body’s response to pathogens and can be helpful in the short term.

What are the diagnostic criteria for CIRS?

The current diagnostic criteria for CIRS are as follows: laboratory abnormalities similar to those seen in published peer-reviewed studies; potential of exposure to a water-damaged building with amplified microbial growth, as detected by the presence of visible mould, water damage, musty odours, or commercial testing.

Do the best treatment protocols for CIRS lead to complete recovery?

Even the best treatment protocols for CIRS that have sufficient scholarly evidence for every step do not necessarily lead to a complete recovery for all patients.

Is chronic inflammatory response syndrome (CIRS) serious?

Chronic inflammatory response syndrome can be a serious condition. And it’s difficult to know what to do about it because it can resemble other conditions whose treatments are entirely different. The first and most important step you can take here is to get the right kind of guidance.

What is chronic inflammatory response syndrome?

Chronic Inflammatory Response Syndrome (CIRS) Explained Chronic Inflammatory Response Syndrome (CIRS) is a multi-system, multi-symptom illness caused by inhaling biotoxins and inflammagens produced by micro-organisms such as mould, bacteria, and actinomycetes found in water-damaged buildings (WDB).

What is inflammation and how can CIRS help?

Inflammation is a natural part of the body’s response to pathogens and can be helpful in the short term. However, when an individual’s immune system is able to detect but not remove biotoxins from the body, the body stays in an inflamed state that only worsens, causing the so-called “chronic inflammatory response” that CIRS is named for.

What is the pathophysiology of CIRS?

The innate immune system continues to create inflammatory cytokines, leading to dysregulation of multiple systems and thus the CIRS diagnosis Patients with CIRS have dysfunction of T reg cells which are converted into pathogenic T lymphocytes via the inflammatory cytokine TGF beta-1

How many symptom clusters do I need to be considered CIRS?

You need to have at least 1 symptom in at least 6 of the 13 symptom clusters to be considered for CIRS. IF you have at least 1 symptom in 8 of 13 symptom clusters, that indicates a high probability of CIRS.

What lab tests should be done to confirm a CIRS diagnosis?

If a patient has a positive exposure history, more than 6 symptom clusters, a positive VCS test, and fulfills the diagnositc criteria of the first 2 tiers, then further confirmatory lab testing must be done to confirm or diprove the CIRS diagnosis.

What are the diagnostic criteria for chronic inflammatory response syndrome (CIRS)?

Patients should present with at least four out of the eight objective serum markers found in CIRS – TGFB1, VIP, MSH, MMP9, C4a, VEGF, ACTH/cortisol and ADH/osmolality. [1] Shoemaker R.C. Ryan JC Vasoactive intestinal polypeptide (VIP) corrects chronic inflammatory response syndrome (CIRS) acquired following exposure to water-damaged buildings.

What are the symptoms of CIRS?

Extremities: Cold hands/feet, discolored hands and feet such as white and red mottling, numbness in parts of the body, tingling, shaky hands, and clawing of fingers or toes Dr. Shoemaker broke CIRS symptoms down into 13 distinct clusters.

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